Palace Malice, who hasn't raced since May, will return to action Sunday.
The two-time Aiken-Trained Horse of the Year is entered in the $100,000 Alydar Stakes at Saratoga Race Course in New York.
Owned by Dogwood Stable in partnership with Three Chimneys Farm, Palace Malice has the No. 6 post position in the 12-horse field. Also in the 1⅛-mile Alydar is Godolphin Racing's Bay of Plenty, who was trained in Aiken.
John Velazquez will ride Palace Malice, and Joel Rosario will be aboard Bay of Plenty, who is in the No. 1 post.
A 5-year-old horse, Palace Malice has been plagued by a series of injuries in 2015. He finished third in the Diablo Stakes at New York's Belmont Park nearly three months ago.
"He's had two or three very minor problems, but they've cost us some pain and time," said Dogwood Stable President Cot Campbell. "We've been getting him ready to get back up and going. We're very excited about getting him back, and we hope to have a great rest of the year with him."
Palace Malice won the Grade 1 Metropolitan Handicap in 2014 and the Grade 1 Belmont Stakes in 2013.